It can work, but not with the hole size you indicate.
Much larger cable diameter is needed at 48A, and take care to not rely on plating, especially on wires.
You can get high current connectors, and usually they have multiple pins to spread the connection.
With this much current, some care is needed to watch the total thermal envelope.
Lots of tracks, all trying to raise the PCB 10' above ambient, can give significant overall heating, and the MOSFETS will add some more to that..
A simple sanity check, is to check a milli-ohms budget :
Let's start at 1 milli-ohm, which is not very much... 48*48*.001 = 2.304 Watts See the problem already ?
What are your MOSFETs Rds ?
I'd suggest using fill areas for all current traces, you are buying the copper anyway, instead of etching it away, use it to spread the heat and lower the total milliohms.
You could also look at oval pads on MOSFETS, or even change to surface mount models.