For what reasons do you want to do this? Is the part to be hand-populated later? I have one hand-soldered part, but I also have several "address assignment resistors" that need to be DNP depending upon the intended "address" of the individual board.
I think, for the resistors, I'll just leave the solder on the pads, and reflow it onto the board without a part.
I think for the hand-soldered part, I will eliminate the solder paste entirely.
You can change the "Solder paste ratio clearance" on every part to "-50%" and that will remove the paste from the pads.