Custom design rules to provide additional breakout alleviation is probably the best way to manage this.
This is what I have for a fine-pitch leaded ADC while also needed 3W clearance
(version 1)
(rule “3W between digital and others”
(constraint clearance(min 0.45mm))
(condition “(A.NetClass == ‘digital’) && (B.NetClass == ‘digital’)”)
)