You have (3) parallel PUs on each I2C signal? If you really need stiff 1.6k I2C PUs, you could just use a single 1.6k R on each signal and delete the (4) redundant ones. That might afford you a cleaner placement where you could avoid your x-over?
There are many more oddities on this layout. Caps with odd footprints sprinkled all over the board and funny track widths plus jerky routing.